MOTS-c + BPC-157 + GHK-Cu + Kisspeptin-10 - Empress

1 Identity

Fixed-ratio four-component article: a copper(II) coordination complex co-lyophilized with three synthetic linear peptides. Not a molecule and not a single substance; a formulation. One component is a metal complex rather than a peptide, and that sets the analytical class of the whole article. and the shorthand "MOTS/BPC/GHK/Kiss". Market names are recorded exactly as found and are not adopted as identity statements. Two component names in this title cover more than one molecule each, and both are fixed on this record: "MOTS-c" covers the human 16-mer and four species and fragment articles, and "kisspeptin-10" covers the human and murine decapeptides, which differ by one terminal residue and 16.00 Da.

Contains MOTS-c + BPC-157 + GHK-Cu + Kisspeptin-10

Sequence

Per component; each component's full identity lives on its own record and is cross-referenced rather than restated. A, MOTS-c: MRWQEMGYIFYPRKLR, 16 residues, free acid, all L; the oxidation inventory is the specification - two methionines at positions 1 and 6, not 1 and 5, one tryptophan at 3, two tyrosines at 8 and 11. B, BPC-157: GEPPPGKPADDAGLV, 15 residues, free acid, no cysteine, no aromatic residue. C, GHK-Cu: ligand H-Gly-L-His-L-Lys-OH as its copper(II) complex, conventionally 1:1. D, Kisspeptin-10: YNWNSFGLRF-NH2, ten residues, the C-terminal primary amide obligatory - this is an RFamide and the free-acid form is a different article, not a lesser grade.

Molecular formula

Per component, never as a sum. MOTS-c C101H152N28O22S2 (free acid); BPC-157 C62H98N16O22; GHK-Cu C14H22CuN6O4; kisspeptin-10 C63H83N17O14 (free base, C-terminal amide). No combined formula is written: a mixture has no molecular formula, and a certificate printing one describes something that does not exist. Salt is stated per component; kisspeptin-10's bis-trifluoroacetate at 1,530.51 is 14.9 percent counterion by weight, and MOTS-c's three arginines and one lysine make its counterion burden significant too.

Average mass

Per component: MOTS-c 2,174.621 Da; BPC-157 1,419.556; GHK-Cu 401.914 (copper 63.546, an isotope-weighted average and not the mass of any single molecule); kisspeptin-10 1,302.462. Worked example at 10 + 10 + 50 + 10 mg, 80 mg total nominal fill: 4.599, 7.044, 124.405 and 7.678 micromol - a molar ratio of 1.00 : 1.53 : 27.05 : 1.67 out of a 1 : 1 : 5 : 1 mass ratio. Copper contributes 7.905 mg, 9.88 percent of gross fill. Named comparators: MOTS-c mono-sulfoxide 2,190.62 and the K14Q polymorph peptide 2,174.58; murine kisspeptin-10 differs by 16 Da.

Monoisotopic mass

Per component. MOTS-c 2,173.10774 Da neutral, [M+2H]2+ 1,087.56115; BPC-157 1,418.7042, [M+H]+ 1,419.7115; GHK-Cu 401.0999 for the 63Cu isotopologue, the 63Cu-to-65Cu envelope at 69.15 to 30.85 being part of the identity; kisspeptin-10 1,301.6305, [M+H]+ 1,302.6378. Two collisions belong here rather than in A footnote. The kisspeptin des-amido free acid has a neutral monoisotopic mass of 1,302.6146, which sits 0.0232 Da - about 18 ppm - from the peptide's own protonated ion at 1,302.6378, so a certificate reporting "1302.6" without naming charge state and adduct has not distinguished product from impurity. And the MOTS-c K14Q polymorph at 2,173.07135 sits 0.03639 Da from the parent neutral, demanding resolving power near 1 in 60,000.

Salt / variant note

(1) the MOTS-C fork: rat 20-mer 2,516.03, mouse 11-mer 1,446.75, the (1-12) and (1-13) fragments at 1,620.91 and 1,777.10, and the K14Q polymorph peptide invisible to accurate mass alone. (2) the kisspeptin fork: human against murine, one terminal residue and 16.00 Da apart, kept on separate catalog numbers by the institutional suppliers but on one name in the consumer channel; and the des-amido free acid, a different article. (3) the copper fork: 1:1 complex 401.914, mono-acetate 461.966, metal-free GHK 340.384, AHK-Cu 415.94. (4) BPC-157: acetate, trifluoroacetate and the arginate salt, the last carried on a separate record in this catalog. (5) ratio: no standard presentation exists.

2 Class & testing panel

Form

Fixed-ratio blend

Testing panel

P5 and P1 — panel definitiontogether, as a union rather than the higher of the two. P5 governs GHK-Cu - copper stoichiometry by ICP-MS, the Cu(II) d-d band, the copper isotope envelope, salt form stated as a finding. P1 governs MOTS-c, BPC-157 and kisspeptin-10. The article is released against both panels in full, per component, with each component released against its full single-article specification on the INPUT material before blending. This is the best-conditioned four-component blend in the catalog, and the arithmetic says so rather than the adjective: every component carries a unique marker residue, which is not true of the copper blend Samson and Delilah elsewhere in this catalog, where GHK-Cu has none at all. Two amino acid analysis constraints govern which markers are usable, and a template method misses both: tryptophan is destroyed by standard 6M HCl hydrolysis, so the tryptophans of MOTS-c and kisspeptin-10 cannot serve as markers however unique they look; and methionine reads low against any sulfoxide present, so isoleucine and not methionine is the primary MOTS-c marker, with methionine reserved as the confirmatory and a performic acid step declared

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

Published literature exists for each component, is graded on that component's record and is cross-referenced from here rather than restated. BPC-157 is graded D, is overwhelmingly rodent and in-vitro, and is heavily concentrated in one research group (Sikiric and colleagues, Zagreb), with registered trials NCT02637284 and NCT07437547 and only three pilot human studies identified by McGuire 2025. MOTS-c's file is mitochondrial-derived-peptide literature originating at the University of Southern California, with an analog rather than the native peptide having entered early human study. Kisspeptin-10's native decapeptide sequence was published in 2001. The GHK-Cu file is graded D. None of it is literature about this mixture, and no published study of this fixed four-component combination has been identified.

4 Storage & specification

Storage

Blue to blue-violet co-lyophilized solid in a Type I amber glass vial with a PTFE-lined closure, headspace displaced with nitrogen and re-blanketed after any subdivision - a laboratory-chemical presentation, non-sterile, carrying no sterility claim and no stoppered-and-crimped injection format. Store at -20 degrees C plus or minus 5 degrees C, tightly closed, desiccated, protected from light. The inert headspace and the light protection are the specific controls for MOTS-c oxidation in the presence of copper, and the label states that reason. A redox-active copper complex at 62.5 percent of the fill shares a vial with the most oxidation-labile peptide in this catalog, which is why inert headspace is a release condition here rather than packaging and why an oxidized-species trend is mandatory. Color is an in-process identity check and is recorded at each handling step. The article is incompatible with strong chelators, reducing agents and phosphate buffers, and the compatible diluent is stated on the label. Reconstituted solution is aliquoted single-use at -80 degrees C.

Shelf life

Provisional 24 months at -20 degrees C plus or minus 5 degrees C, desiccated, light-protected and under inert headspace, from QA release - all four component intervals being 24 months - and provisional pending this company's own data. The blend runs its own protocol and does not inherit the component studies, with a mandatory 6-month interim pull on each of the first three lots and a headspace-integrity check accompanying every pull. Attributes: per-component net content, every pairwise ratio, copper stoichiometry by ICP-MS, the d-d band lambda-max, free-ligand GHK at 340.186, methionine sulfoxide at MOTS-c positions 1 and 6 and each Trp3 oxidation product reported individually, kisspeptin Trp-oxidation and Asn-deamidation species reported individually, iso-aspartate at the BPC-157 Asp11-Gly13 site, water and counterion per component. The oxidation impurities are the stability-indicating attributes on this article rather than gross purity, and the presence of copper is the reason the trigger for shortening the interval is set tighter than on the MOTS-c record alone.