DSIP + Selank + CJC-1295 + Ipamorelin - Hypness

1 Identity

Fixed-ratio four-component article: an all-L nonapeptide free acid, an all-L heptapeptide free acid, a 30-residue growth-hormone-releasing-factor analogue bearing D-Ala2 and an N-epsilon-maleimidopropionyl albumin-binding conjugate at Lys30, and a five-residue C-terminally amidated pentapeptide carrying three non-proteinogenic or D residues. No metal center, no disulfide. The third component'S name is the unresolved one: CJC-1295 is used in trade for two different molecules, the DAC-bearing maleimide conjugate at 3,647.25 Da and, as CJC-1295 no DAC, Modified GRF (1-29) at 3,367.954 Da, 279.296 Da lighter. This record specifies the DAC-bearing conjugate and does not accept the bare abbreviation.

Contains DSIP + Selank + CJC-1295 + Ipamorelin

Sequence

Stated per component. DSIP is H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH, that is WAGGDASGE. Selank is H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH. CJC-1295 (DAC:GRF) is H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys30(N-epsilon-3-maleimidopropionyl)-NH2. Ipamorelin is Aib-His-D-2-Nal-D-Phe-Lys-NH2. Two free acids and two amides share the vial, and a free-acid form of either amidated component is a specified impurity, not a synonym.

Molecular formula

Stated per component. A mixture has no combined formula and none is written. DSIP C35H48N10O15. Selank C33H57N11O9. CJC-1295 (DAC:GRF) C165H269N47O46. Ipamorelin C38H49N9O5. No component contains sulfur, which removes the isotope-envelope shortcut and puts the whole identity burden on accurate mass, retention and MS/MS. The maleimide ring on the third component is a Michael acceptor, and its ring-opened maleamic acid hydrolysis product at +18.011 Da is a named impurity rather than an incidental finding.

Average mass

Per component, on IUPAC 2021 abridged conventional atomic weights: DSIP 848.824 Da; Selank 751.887 Da; CJC-1295 (DAC:GRF) 3,647.25 Da; ipamorelin 711.87 Da. AT A stated nominal 4 + 4 + 2 + 2 mg fill, 12 mg total, the 2 : 2 : 1 : 1 mass ratio is a molar ratio of 8.594 : 9.702 : 1.000 : 5.123 - 4.71240, 5.31995, 0.54836 and 2.80950 micromol. A 3.6 kDa conjugate against a 712 Da pentapeptide amide is nowhere near equimolar at any convenient mass ratio, and a document treating the mass ratio as a molar ratio is wrong on its face.

Monoisotopic mass

Per component. DSIP 848.33006, [M+H]+ 849.33734. Selank 751.43407, [M+H]+ 752.44135. CJC-1295 (DAC:GRF) 3,645.0155, observed multiply charged, [M+3H]3+ 1,216.0124 and [M+4H]4+ 912.2612. Ipamorelin 711.3857, [M+H]+ 712.3930. The separation that matters most is 279.296 Da average, between the DAC-bearing conjugate specified here and Modified GRF (1-29) sold as CJC-1295 no DAC, a difference no rounded figure or unlabeled charge envelope will show.

Salt / variant note

(1) the DAC fork, the defining substitution risk on this article: CJC-1295 (DAC:GRF) 3,647.25 against Modified GRF (1-29) 3,367.954, the latter routinely sold as CJC-1295 no DAC. A blend built on the second and sold under this title is a different article. (2) the maleimide state: intact ring against the ring-opened maleamic acid at +18.011 Da, and against a maleimide already quenched by an amine adduct. (3) Selank fork: 751.887 against 792.940. (4) ipamorelin: the free-acid form at 712.86 against the specified amide at 711.87. (5) ratio: no standard located. (6) Counterion determined per component, acetate against trifluoroacetate.

2 Class & testing panel

Form

Fixed-ratio blend

Testing panel

P1 and P3 — panel definitionas a union, run per component and never once for the vial. P1 governs DSIP and Selank. P3 is engaged twice and independently - D-Ala2 in the CJC-1295 backbone, and Aib1, D-2-Nal3 and D-Phe4 in ipamorelin - so chiral amino acid analysis is mandatory and is judged against each component's own expected D-content, never a pooled figure. Aib is achiral, carries no chiral limit, and is shown present by MS/MS. Two configuration points are written into the method for this article rather than inherited. First, Aib is a routine internal standard for amino acid analysis and here it is an analyte, so the default configuration is invalid on this vial and would fail silently rather than as an out-of-specification result. Second, the DSIP marker is routed off tryptophan, which standard acid hydrolysis destroys, and onto glycine by difference against an independently fixed Selank quantity; the dependency is stated on the specification rather than buried in the method

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

What follows reports study design and provenance, not a conclusion about effect. Published literature exists for each component, sits on that component's own record in this catalog, and is cross-referenced here rather than restated: the record for CJC-1295 (DAC:GRF) carries sponsor-era clinical work from the ConjuChem program, and the ipamorelin record a substantial preclinical and analytical corpus. None of it is literature about this mixture, and material published under the name CJC-1295 without a DAC statement cannot be attributed to either molecule with confidence, which is a limit on the literature and not on the components. Combination literature: none identified. No published study of this fixed four-component combination was identified; that is a statement about the published record.

4 Storage & specification

Storage

White to off-white co-lyophilized cake in Type I amber glass with a PTFE-lined closure, nitrogen headspace and in-pack desiccant, stored at -20 degrees C plus or minus 5 degrees C, desiccated and protected from light. Non-sterile laboratory chemical, no sterility claim, no injection format. The dry state is part of the specification here rather than a convenience: the intact maleimide is a Michael acceptor and three of the four components carry free amines, so solution is not a storage form for this article - it is single-use, with no hold time and no refreeze.

Shelf life

Provisional 24 months at -20 degrees C plus or minus 5 degrees C, desiccated and light-protected. It is the shortest of the four component intervals and is provisional pending this company's own data; the blend runs its own protocol and inherits no component study. Stability-indicating attributes are per-component net content, the component ratios, maleamic acid at +18.011 Da, any amine-adduct species, tryptophan oxidation on DSIP, amide-to-acid conversion on the two amidated components, water and counterion.