AOD-9604 + CJC-1295 + Ipamorelin + MOTS-c - Inferno

1 Identity

Fixed-ratio four-component article: a disulfide-closed 16-residue somatropin-chain analog, a 30-residue peptide-maleimide conjugate, a five-residue pentapeptide amide with two non-proteinogenic residues, and a 16-residue mitochondrially encoded peptide free acid, co-lyophilized. No metal center. Each component's full identity lives on its own record in the catalog and is cross-referenced rather than restated. The second name in the title is ambiguous as always — the DAC-bearing conjugate at 3,647.250 Da against "CJC-1295 no DAC", trade usage for Modified GRF (1-29) at 3,367.954 Da — so this record is written for the DAC-bearing conjugate and the specification names it in full.

Contains AOD-9604 + CJC-1295 + Ipamorelin + MOTS-c

Sequence

Per component; the full sequences live on the component records and are not restated. Blend-relevant facts only: AOD-9604 is H-YLRIVQCRSVEGSCGF-OH with one disulfide, Cys7-Cys14, its N-terminal tyrosine appended and non-native; CJC-1295 (DAC:GRF) is the tetrasubstituted GHRH(1-29) scaffold plus Lys30 bearing a 3-maleimidopropionyl group, D-Ala2 its sole D-center; ipamorelin is Aib-His-D-2-Nal-D-Phe-Lys-NH2; MOTS-c is H-MRWQEMGYIFYPRKLR-OH free acid, with methionines at positions 1 and 6 — not 1 and 5 — one tryptophan at 3 and tyrosines at 8 and 11.

Molecular formula

Per component; a mixture has no combined formula and none is written. AOD-9604 C78H123N23O23S2 disulfide-closed; CJC-1295 (DAC:GRF) C165H269N47O46; ipamorelin C38H49N9O5; MOTS-c C101H152N28O22S2 free acid, mono-trifluoroacetate C103H153F3N28O24S2. Counterion is a measured finding per component; MOTS-c carries three arginines and a lysine, so its counterion burden is a first-order quantity rather than a footnote.

Average mass

Per component, on IUPAC 2021 abridged conventional atomic weights: AOD-9604 1,815.100 Da; CJC-1295 (DAC:GRF) 3,647.250 Da; ipamorelin 711.868 Da; MOTS-c 2,174.621 Da. AT A nominal 10 mg each, 40 mg total, the 1:1:1:1 mass ratio is a molar ratio of 2.01 : 1.00 : 5.12 : 1.68 — 5.50934, 2.74179, 14.04755 and 4.59850 micromol. A fivefold molecular-weight spread makes an equal-mass fill nothing like equimolar, and a document treating the mass ratio as a molar ratio is wrong on its face.

Monoisotopic mass

Per component. AOD-9604 1,813.86036, [M+H]+ 1,814.8676; CJC-1295 3,645.01548, [M+3H]3+ 1,216.0124; ipamorelin 711.3857, [M+H]+ 712.3930; MOTS-c 2,173.10774, [M+2H]2+ 1,087.56115. Three separations govern acceptance: AOD-9604 against genuine hGH(176-191) at 1,797.86544, where a mono-oxidized fragment is elementally identical to closed AOD-9604 and only MS/MS localization separates them; CJC-1295 against Modified GRF (1-29) at 3,365.89358, a 279.121 Da gap no instrument can miss and a paper specification routinely does; and the MOTS-c K14Q polymorph peptide at 2,173.07135, 0.03639 Da from the parent and 0.01213 Da on the 3+ ion, demanding resolving power near 1 part in 60,000. No single blend molecular weight is printed.

Salt / variant note

Five forks govern what is actually in the vial. (1) the fragment fork on the first component: AOD-9604 1,815.100 against genuine hGH(176-191) 1,799.101, one Tyr-for-Phe apart, plus the reduced open chain at +2.016 Da — and the market ships these two under each other's names in both directions. (2) the DAC fork: 3,647.250 against "CJC-1295 no DAC" 3,367.954, and sermorelin 3,357.933 besides. (3) the maleamic-acid degradant at +18.015 Da. (4) MOTS-c neighbors: K14Q polymorph peptide 2,174.58, rat 20-mer 2,516.03, mouse 11-mer 1,446.75, (1-12) 1,620.91, (1-13) 1,777.10, mono-sulfoxide 2,190.62. (5) Counterion per component; the ratio is not standardized across the market.

2 Class & testing panel

Form

Fixed-ratio blend

Testing panel

P1 and P3 — panel definitionas a union, run per component. P1 governs AOD-9604, with its intramolecular disulfide as a named identity attribute, and MOTS-c. P3 is engaged twice — D-Ala2 in CJC-1295, Aib1/D-2-Nal3/D-Phe4 in ipamorelin — so chiral amino acid analysis runs against each component's own expected D-content and never as a pooled figure; Aib is achiral and is shown present by MS/MS. The conjugate adds two tests no panel letter carries: intact maleimide content against the maleamic-acid degradant, and a free-thiol determination, which on this composition is not optional. The reason is a formulation finding specific to this vial: the article puts a thiol-reactive maleimide and a disulfide-bearing peptide in one solid, so partial reduction yields free thiols that conjugate to the maleimide at roughly 5,460 Da, both components falling together with no new small-molecule impurity — a change invisible to a total net peptide result and to RP-HPLC purity alike. One further constraint sits on the fourth component: MOTS-c's three unique markers here are precisely the three residues amino acid analysis handles worst, so this article is not released on a single unmodified hydrolysis

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

Published literature exists for each component, is graded on that component's record and is cross-referenced from here rather than restated. None of it is literature about this four-component mixture: no published study of this fixed combination, at any ratio, has been identified, and no consensus specification for it exists. What governs acceptance of a blend lot is therefore the per-component evidence read alongside a measured ratio, not a citation for the combination.

4 Storage & specification

Storage

Co-lyophilized solid, Type I amber glass with nitrogen headspace, held at -20 degrees C plus or minus 5 degrees C, desiccated and protected from light. Non-sterile laboratory chemical; no sterility claim. Each condition is written for a stated reason rather than as housekeeping: MOTS-c carries two methionines, a tryptophan and two tyrosines; AOD-9604 contributes a redox-sensitive disulfide; the maleimide hydrolyzes in the presence of water, so Karl Fischer is a release attribute; and any thiol-containing diluent is excluded on the label.

Shelf life

Provisional at 24 months at -20 degrees C plus or minus 5 degrees C, desiccated and protected from light. The retest-limiting attributes are maleimide hydrolysis to the maleamic acid at +18.015 Da, methionine sulfoxide and tryptophan oxidation products on MOTS-c, the reduced open-chain AOD-9604 at +2.016 Da, and the thiol-maleimide adduct.