N-Acetyl Semax + N-Acetyl Selank + Pinealon + PE-22-28 - Illumineuro / Einstein

1 Identity

Fixed-ratio four-component article: two N-terminally acetylated all-L heptapeptides, an all-L tripeptide free acid of the Khavinson short-peptide series, and an unmodified all-L heptapeptide free acid that is a shortened analogue of the spadin sequence. No metal center, no acyl chain beyond the terminal acetyls, no conjugate, no disulfide, no non-proteinogenic residue.

Contains N-Acetyl Semax + N-Acetyl Selank + Pinealon + PE-22-28

Sequence

Per component, cross-referenced. N-Acetyl Semax Ac-Met-Glu-His-Phe-Pro-Gly-Pro-OH, free acid, not amidated. N-Acetyl Selank Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH, the catalog default free acid. Pinealon H-L-Glu-L-Asp-L-Arg-OH. PE-22-28 H-Gly-Val-Ser-Trp-Gly-Leu-Arg-OH (GVSWGLR). The article as named specifies the acetylated free acids, not the amidates, and that distinction carries a 0.984 Da consequence on two of the four components.

Molecular formula

Per component; a mixture has no combined formula and none is written. N-Acetyl Semax C39H53N9O11S; N-Acetyl Selank C35H59N11O10; Pinealon C15H26N6O8; PE-22-28 C35H55N11O9. The Semax-family component is the only sulfur-bearing chain, so the isotope envelope assigns it without reference to retention. PE-22-28 is the only tryptophan-bearing chain, which matters for detection and for hydrolysis. Counterion is measured per component; all four are supplied as acetate salts at stoichiometries that are not fixed.

Average mass

Per component, on IUPAC 2021 abridged conventional atomic weights: N-Acetyl Semax 855.965 Da; N-Acetyl Selank 793.924 Da; Pinealon 418.407 Da; PE-22-28 773.893 Da. AT A nominal 10 + 10 + 10 + 10 mg fill, 40 mg total, the 1 : 1 : 1 : 1 mass ratio is a molar ratio of 1.000 : 1.078 : 2.046 : 1.106 - 11.68272, 12.59566, 23.90017 and 12.92168 micromol. The tripeptide is present at twice the molar quantity of the acetylated heptapeptide at equal mass. No single blend 'molecular weight' is printed.

Monoisotopic mass

Per component. N-Acetyl Semax 855.3585, [M+H]+ 856.3658. N-Acetyl Selank 793.4446, [M+H]+ 794.4519. Pinealon 418.18121, [M+H]+ 419.18849. PE-22-28 773.41842, [M+H]+ 774.42570. The separations that matter are 0.9840 Da internal forks on both acetylated components - each free acid against its own amidate, at 854.981 and 792.940 average - so a nominal-mass instrument cannot release this article. Methionine sulfoxide on the Semax-family component sits +15.9949 Da from parent.

Salt / variant note

Two of the four components are supplied in both a free-acid and an amidated form: N-Acetyl Semax at 855.965 against N-Acetyl Semax Amidate at 854.981, and N-Acetyl Selank at 793.924 against N-Acetyl Selank Amidate at 792.940. The two forms differ by about one dalton, so each component has to be confirmed on its own rather than assumed from the blend title. The observed consumer channel ships the amidates almost exclusively, so a product sold under this blend title is at least as likely to contain the amidates as the free acids named.

2 Class & testing panel

Form

Fixed-ratio blend

Testing panel

P1 — panel definitionfor all four components, run per component and never once for the vial; the union adds nothing beyond P1. Two components are N-terminally acetylated, which blocks Edman degradation on those two, so sequence confirmation across the article is MS/MS or nothing. The dynamic-range problem of the three-component neuro article persists here: a 418 Da tripeptide sits alongside three 773-856 Da heptapeptides

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

Published literature exists for each component, is graded on that component's record and is cross-referenced rather than restated; the PE-22-28 file traces to an originating French academic program and is the smallest of the four, while the Pinealon file sits within the Khavinson short-peptide corpus with its methodological limitations stated on that record. None of it is literature about this mixture.

4 Storage & specification

Storage

White to off-white co-lyophilized cake in Type I amber glass with a PTFE-lined closure, nitrogen headspace, in-pack desiccant; non-sterile laboratory chemical, no sterility claim, no intranasal or unit-dose format. Store at -20 degrees C plus or minus 5 degrees C, desiccated, protected from light. Light and oxygen control is doubly load-bearing on this article - the Met1 thioether on one component and the Trp4 indole on another are both photo- and oxygen-labile, and the label states both reasons.

Shelf life

Provisional 24 months at -20 degrees C plus or minus 5 degrees C, desiccated and light-protected, the shortest of the four component intervals, pending this company's own data. Stability-indicating attributes are per-component net content, all three pairwise ratios, methionine sulfoxide, tryptophan oxidation products reported individually, amidate growth at the 0.9840 Da offset on each acetylated component, free arginine and free glutamate as tripeptide markers, water and counterion.