J147 + Dihexa + Noopept - capsule blend

1 Identity

Fixed-ratio three-component oral capsule article: one trifluoromethyl-bearing acylhydrazone small molecule containing no amino acid residue, one N-acylated dipeptide-derived analogue carrying a 6-aminohexanamide tail, and one dipeptide ethyl ester with an N-phenylacetyl cap. No free peptide, no metal, no disulfide.

Sequence

Not applicable to any component; none has a sequence and none is written. Structural statements replace them. J147: N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide, an acylhydrazone with no amino acid residue at all. Dihexa: CH3(CH2)4CO-Tyr-Ile-NH-(CH2)5-CONH2, two peptide bonds plus a terminal carboxamide, derived by truncation from an angiotensin IV analogue series. Noopept: PhAc-Pro-Gly-OEt, one peptide bond, one N-terminal phenylacetyl cap, one C-terminal ethyl ester, a single stereocenter at the proline alpha carbon.

Molecular formula

Per component; a mixture has no combined formula and none is written. J147 C18H17F3N2O2. Dihexa C27H44N4O5. Noopept C17H22N2O4; its governing degradant, the free acid after ester hydrolysis, is C15H18N2O4. J147 is the only fluorinated component and that single fact supplies the article's cleanest orthogonal handle, set out under the certificate requirements below.

Average mass

Per component, IUPAC 2021 abridged conventional atomic weights: J147 350.341 from C18H17F3N2O2, agreeing with the 350.34 that listings print for CAS 1146963-51-0; Dihexa 504.672; Noopept 318.373, with the ester-hydrolysis free acid at 290.319. Worked example at a stated nominal 10 + 6 + 30 mg per capsule, 46 mg total actives: 28.544, 11.889 and 94.229 micromol - a 2.40 : 1.00 : 7.93 molar ratio. That fill is a stated nominal for arithmetic, not a market standard; the observed single-article channel sells Dihexa at 5 mg per capsule and Noopept at 30 mg per capsule. No single blend molecular weight is printed; a mixture does not have one.

Monoisotopic mass

Per component, neutral: J147 350.1242; Dihexa 504.3312; Noopept 318.1580. All three are small, singly charged, well within one acquisition and require no deconvolution, so intact mass is genuinely informative here rather than a formality. J147's trifluoromethyl group gives it an isotope and defect signature the other two cannot imitate.

Salt / variant note

(1) ratio: none standard. (2) J147 isomer state: E/Z pair against the defined (E) isomer, sold under different registry numbers at the same formula and the same 350.341 mass - a difference no mass measurement detects and which must be declared and measured. (3) Noopept ester: the ethyl ester is the labile group and the 290.319 free acid is its named degradant, not an unknown peak. (4) Dihexa salt and solvate: to be declared per lot. (5) presentation: capsule against bulk powder, which is a formulation variable rather than a chemical one and is recorded as such.

2 Class & testing panel

Form

Fixed-ratio blend

Testing panel

P6 — panel definitionfor J147 and Noopept, P3 for Dihexa, run per component and never once for the capsule. The panel choice carries A consequence that governs the whole certificate: net peptide content is not a measurand for any of the three, because none of them is a peptide. Each is assayed as w/w content against a declared salt, solvate and isomer state, and a certificate printing net peptide content, amino acid analysis as a content method, or an endotoxin figure has run a peptide template against three small molecules

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

Published literature exists for Dihexa and Noopept, is graded on those records and is cross-referenced rather than restated. J147 carries no literature grading in this catalog.

4 Storage & specification

Storage

Sealed containers with a desiccant, protected from light and moisture, held at ambient or below on the component data. The controlling chemistry is hydrolytic rather than oxidative - an ethyl ester on one component and an acylhydrazone on another are both water-sensitive linkages - so a capsule shell equilibrating with ambient humidity is a formulation variable and not a packaging detail.

Shelf life

The capsule is dated from its date of manufacture and carries the retest interval printed on its specification. It runs its own stability protocol and inherits no component study, and the question that protocol answers rather than assumes is whether the capsule shell's water content drives ester hydrolysis on the Noopept component and acylhydrazone exchange on J147 at rates the bulk powders do not show. The stability-indicating attributes are per-component content, the three-way ratio, the Noopept free acid, J147 isomer ratio, water and any new peak above 0.10 percent.