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Human Relaxin-2

Also indexed as Relaxin-2, H2 relaxin, RLN2

1 Identity

Two-chain peptide hormone, A chain 24 residues and B chain 29 residues, held together by two interchain disulfides with one intrachain disulfide in the A chain. Insulin-superfamily architecture. Not a linear peptide, and not synthesizable as one without a directed folding step. Serelaxin is the recombinant pharmaceutical form.

Sequence: A chain 24 residues, B chain 29 residues. Disulfide connectivity A10-B10, A15-B22 interchain and A11-A16 intrachain. The connectivity is the molecule: a correctly composed preparation with scrambled disulfides has the same mass and is not this article.
Molecular formula: C256H408N74O74S8 for the correctly folded two-chain molecule.
Average mass: Approximately 5963 Da for the folded two-chain molecule (derived).
Monoisotopic mass: Not available from an authoritative source.
Salt / variant note: B7-33, also recorded in this catalog, is a single-chain relaxin analogue, not relaxin, and the two must never be reconciled to one record. Also relaxin-1 and relaxin-3, INSL3 and INSL5, and insulin and IGF-1 and IGF-2, which share the architecture. Note the internal collision: this catalog holds IGF-1 full length, IGF-1 LR3 and Human Relaxin-2, all insulin-superfamily, all disulfide-dependent, and all defeated by the same analytical shortcut.

2 Class & testing panel

Form: Single article
Testing panel: Special-class panel — panel definition

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

Structure and connectivity are settled in the literature. The evidence from the clinical program is negative and is not reproduced here.

4 Storage & specification

Storage: Lyophilized, -20 degrees C or below, desiccated, protected from light. Reconstituted material at 2 to 8 degrees C for short periods only and never re-frozen; aggregation on freeze-thaw is the dominant failure mode for folded proteins, and it is not visible to the eye.
Shelf life: Not assignable without measured stability data on the folded form.

This record reports identity, specification and study design. It does not state what the article does in a human body. Supplied under the caution: “CAUTION: Contains a new drug for investigational use only in laboratory research animals or for tests in vitro. Not for use in humans.”