Emideltide

1 Identity

Synthetic linear nonapeptide — INN of the DSIP molecule. DSIP and delta sleep-inducing peptide; EMIDELTIDE is the International Nonproprietary Name. UNII YN28Z5YZ73. CAS 62568-57-4 and 69431-45-4. No settled trade alias appears across the four tracked seller catalogs.

Sequence

H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH (WAGGDASGE). Identical, residue for residue and terminus for terminus, to the DSIP record. All-L nonapeptide, free N-terminal alpha-amine, free C-terminal carboxylic acid, no cysteine, no disulfide, no D-residue, no non-proteinogenic residue, no terminal cap. Gly3, Gly4 and Gly8 are achiral, giving six stereocenters. Two side-chain carboxylates (Asp5, Glu9) plus the C-terminal carboxylate against one alpha-amino group.

Molecular formula

C35H48N10O15 (free acid). One reagent catalog sells the acetate and writes it C35H48N10O15 . XC2H4O2, leaving stoichiometry as X, which is the correct convention for a salt of undeclared ratio. The INN denotes the free acid, and that assignment is settled against NCATS, ChemSpider and a commercial catalog.

Average mass

848.824 Da, from the nonapeptide composition with IUPAC 2021 conventional atomic weights. A value of 848.814 also circulates, and the two differ by 0.010 Da purely because of the atomic-weight convention, not because either is wrong; the 848.8 printed by one reagent catalog rounds both. The same reconciliation is carried on the DSIP record, deliberately duplicated across the pair so that neither record can be read alone and misunderstood.

Monoisotopic mass

848.33006 Da neutral. Working ions: [M+H]+ m/z 849.33734, [M-H]- m/z 847.32278. A plus or minus 5 ppm window on the neutral is plus or minus 0.0042 Da. The C-terminal amide analog at 847.34605 sits 0.98 Da below the free acid and is the substitution the identity method exists to exclude.

Salt / variant note

Multi-molecule name — five chemically distinct articles circulate across this shelf, each separable by arithmetic. (1) Free acid, the INN article: C35H48N10O15, 848.824 avg / 848.33006 mono. (2) C-terminal amide, WAGGDASGE-NH2: C35H49N11O14, 847.840 avg / 847.34605 mono, 0.98 Da light, invisible on a unit-resolution quadrupole and the single likeliest wrong molecule to pass a nominal-mass identity test. (3) N-acetyl DSIP free acid: C37H50N10O16, 890.861 avg / 890.34063 mono, plus 42.037 on the parent and listed separately in the catalog. (4) Acetate against trifluoroacetate salt of the same peptide, differing materially in net peptide content. (5) Deletion sequences: des-Gly at minus 57.02 Da and des-Ala at minus 71.04 Da on a sequence carrying three Gly and two Ala. Note the naming variant that is not a chemical one: the same molecule is shelved as DSIP by sellers and as Emideltide by regulators and institutional suppliers, so a supplier audit or a market survey run under one name misses the other and returns a false negative.

2 Class & testing panel

Form

Single article

Testing panel

P1 — panel definition

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

The evidence is identical to the DSIP record, because it is the same molecule; study types and identifiers only. Bibliometric: 518 PubMed records for "delta sleep-inducing peptide", 1977 to 2026, predominantly animal and biochemical. Human interventional literature: roughly nine studies, all 1981 to 1992, most from one group in Basel, and nothing interventional in humans since. Monti and colleagues, Int J Clin Pharmacol Res 1987, PMID 3583493, a double-blind crossover polysomnographic randomized controlled trial in chronic insomniacs. Bes and colleagues, Neuropsychobiology 1992, PMID 1299794, a double-blind matched-pairs parallel-group study, 16 patients. Reviews: PMID 6145137; PMID 3550726; PMID 16539679. Authors' own conclusions are reproduced verbatim on the evidence page and are not paraphrased here. Nothing published under the INN that is not also indexed under the abbreviation was located. Evidence grade D.

4 Storage & specification

Storage

Lyophilized powder, acetate salt preferred over trifluoroacetate and specified on the purchase order. Store at -20 degrees C or below, desiccated, in amber or foil-overwrapped vials. The N-terminal tryptophan is photo-oxidation sensitive and the powder is hygroscopic, so light and moisture control are release-relevant and not housekeeping. Warm sealed vials to room temperature inside the desiccator before opening, to prevent condensation onto cold powder.

Shelf life

Provisional 24-month retest interval at -20 degrees C, desiccated, in the sealed primary container. It is provisional and labeled as such, set from the general solid-state behavior of unmodified linear peptides and not from data on this material. It is replaced by the company's own ICH-format stability study, placing lot 1 on long-term (-20 degrees C) and accelerated (25 degrees C and 60 percent relative humidity) arms with pulls at 0, 3, 6, 12, 18 and 24 months; the first in-house pull that fails shortens the interval to the last passing point. Because the pair is one molecule, one stability study serves both records and a second must not be commissioned.