Adamax

1 Identity

Synthetic adamantane-conjugated heptapeptide (covalent small-molecule/peptide conjugate). sold by mass as 'Adamax 1032'.

Sequence

Adamantane-1-carbonyl-Met-Glu-His-Phe-Pro-Gly-Pro-Gly-NH2 - the Semax heptapeptide MEHFPGP carrying an adamantane-1-carbonyl group on the N-terminal alpha-amine, extended by one glycine, terminating in a C-terminal primary amide. This is the only arrangement that satisfies the laboratory-declared formula C50H69N11O11S, and it was reached by arithmetic rather than by assumption: subtracting the adamantane-1-carbonyl monoconjugate of free-acid Semax (C48H65N9O11S) from the declared formula leaves exactly C2H4N2, which is one glycine residue plus the acid-to-amide conversion. All seven parent residues are L-proteinogenic; no D-residue, no non-proteinogenic residue, no chiral method required. The attachment site is not settled in any public monograph - the manufacturer declares it in writing and the company confirms it by proton and carbon-13 NMR before a specification is issued. Supplied as the acetate or trifluoroacetate salt, counterion identified and quantified rather than assumed.

Molecular formula

C50H69N11O11S (free base, adamantane-modified article as declared by the contract laboratory)

Average mass

1032.228 Da (C50H69N11O11S), from the formula. Three independent sellers state 1032.24 for this article, two of them carrying the mass in the product name.

Monoisotopic mass

1031.4899 Da. [M+H]+ 1032.4972; [M+2H]2+ 516.7522; [M-H]- 1030.4826.

Salt / variant note

This is the catalog'S worked example - at least four chemically distinct molecules and one refusal-to-state are sold under this one name. (1) The adamantane-modified article, Ada-CO-MEHFPGP-Gly-NH2, C50H69N11O11S, 1032.23 average / 1031.4899 monoisotopic. Three sellers list it, one shipping 10 mg and another 13 mg. (2) the non-adamantyl article with no cage in it at all: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-OH, C44H61N11O13S, 984.10 average / 983.4171 monoisotopic. This is what one seller ships under the name Adamax and what a second manufacturer produces under the name Adamax - and that seller's own product text calls it an analogue of Semax with an adamantane portion while publishing a formula containing no adamantane. Two independent manufacturers, the same non-adamantyl molecule, the same name, 48.13 Da lighter than the real article. (3) A C-terminal-adamantyl claim with no number behind it: one seller lists 'Adamax' as Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ad-NH2 and states the molecular weight as approximately 1100-1300 g/mol depending on adamantyl configuration. A 200 Da stated range is not a specification and cannot be reconciled with either molecule above. Another catalog carries 'Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Adamantane' with no formula and no mass. (4) the two substitutions the contract laboratory actually observed in incoming samples: Semax itself, the unconjugated starting material, C37H51N9O10S, 813.93 / 813.3480 - 218.30 Da below the real article; and N-acetyl Semax amidate, C39H54N10O10S, 854.98 / 854.3745, CAS 2920938-90-3 - 177.25 Da below. Both are cheaper, both are freely available, both were arriving labeled Adamax. (5) Parent-family arithmetic: Semax amide C37H52N10O9S 812.94 / 812.3639; N-acetyl Semax free acid C39H53N9O11S 855.97 / 855.3585, one dalton from the amidate and routinely confused with it; des-adamantyl of the real article, H-MEHFPGP-Gly-NH2, C39H55N11O10S 870.00 / 869.3854, the direct process residue if the conjugation step fails; and the plain monoconjugate Ada-CO-MEHFPGP-OH, C48H65N9O11S 976.16 / 975.4524, which is 56.07 Da light. (6) Degradation and over-reaction space of the real article: methionine sulfoxide C50H69N11O12S 1048.23 / 1047.4848, plus 16.00; the bis-adamantoyl over-conjugate C61H83N11O12S 1194.46 / 1193.5943, plus 162.23; and the free-acid form Ada-CO-MEHFPGP-Gly-OH, C50H68N10O12S 1033.21 / 1032.4739, exactly 0.98 Da heavier and inside any tolerance stated in whole daltons.

2 Class & testing panel

Form

Single article

Testing panel

P2 — panel definition

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

No PubMed-indexed study was identified under this trade name - no synthesis paper, no independent physicochemical characterization, no animal study and no controlled human trial. The parent heptapeptide Semax has a substantial, largely Russian-language rodent and in-vitro literature and a Russian regulatory approval; neither transfers to a covalently modified analogue, and the citation index page carries that literature explicitly labeled as parent-compound literature with the structural difference stated at the top.

4 Storage & specification

Storage

Lyophilized solid in a Type I amber glass vial with a nitrogen-flushed headspace, elastomeric stopper and aluminum crimp seal. Labeled: store at -20 degrees C plus or minus 5 degrees C, protect from light and moisture, equilibrate the sealed vial to room temperature before opening to prevent condensation onto the cake. The nitrogen flush is a specification and not a preference - methionine at position 1 of the parent sequence is oxidation-labile. Ships ambient with a labeled cumulative excursion allowance of 120 hours at or below 30 degrees C recorded on the shipping record; gel packs at 2-8 degrees C where transit exceeds that; a single-use temperature logger travels in every export carton.

Shelf life

Provisional 12 months at -20 degrees C plus or minus 5 degrees C from the date of QA release, stated as provisional pending the company's own stability data, and not started while the identity gate is open. The interval extends to 24 and then 36 months only on real-time data at 12, 18, 24 and 36 months, supported by accelerated data at 40 degrees C / 75% RH at 1, 3 and 6 months, with methionine sulfoxide, total related substances and Karl Fischer water as the stability-indicating attributes. Every vial carries a printed retest date and the inventory system enforces first-expiry-first-out against that date, not against receipt date.