ACE-083

1 Identity

Recombinant Fc fusion protein — human follistatin 288 domain fused to an IgG2 Fc. Not a synthetic peptide. both used only occasionally; no INN has been assigned. Offered by one seller as "ACE-083 1mg".

Sequence

Recombinant fusion protein, sequence not reproduced. Approximately 60 kDa as a homodimer.

Molecular formula

Not applicable to a recombinant Fc fusion protein. No single molecular formula describes a glycosylated Fc fusion, and any certificate printing one is describing a theoretical backbone that is not the material in the vial.

Average mass

Not applicable as a single value. Approximately 60 kDa for the glycosylated homodimer. No authoritative mass has been located, so no exact figure is carried.

Monoisotopic mass

Not available: monoisotopic mass is undefined for a glycosylated 60 kDa fusion protein.

Salt / variant note

Every other myostatin-pathway biologic in the catalog collides with it, and none can be distinguished from another by intact mass, SDS-page or size-exclusion chromatography: trevogrumab (Regeneron, anti-GDF8 IgG4, approximately 144 kDa backbone), GDF-8 propeptide, follistatin 344 and follistatin 315 — which are the natural parent of this article's active domain and are separately recorded here — apitegromab, bimagrumab, domagrozumab, landogrozumab, stamulumab, and ACE-031, a distinct Acceleron article, an ActRIIB-Fc trap, already recorded at its own entry and a different protein from this one.

2 Class & testing panel

Form

Single article

Testing panel

Special-class panel — panel definition

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

Program-level evidence only. Acceleron ran Phase 2 studies in FSHD and CMT; both were discontinued for lack of functional benefit, notwithstanding the increases in muscle volume the studies reported. There is no evidence base for the article as supplied by research-chemical sellers, because what those sellers ship has never been shown to be the originator's molecule.

4 Storage & specification

Storage

Lyophilized, at -20 degrees C or below, desiccated and protected from light; reconstituted material at 2-8 degrees C for short periods only and never refrozen. Aggregation on freeze-thaw is the dominant failure mode for Fc fusions and is not detectable by eye.

Shelf life

Not assignable. No stability data exists for this article outside the originator's discontinued program.