5-Amino-1MQ

1 Identity

Non-peptide small molecule — quaternary N-methylquinolinium salt. vendor shorthand "NNMTi". Not a peptide and not an abbreviation of one.

Sequence

No defined sequence — not a peptide, and no peptide bond is present anywhere in the structure. The article is a quaternized aromatic bicyclic heterocycle: quinoline carrying a methyl group on the ring nitrogen, which makes that nitrogen a permanently charged quaternary center, and a primary amine at ring position 5. Achiral: there is no stereocenter in the structure, so an enantiomeric impurity cannot exist and a chiral method must not be added to it by reflex. Because the cation is permanent, the article is always shipped as a salt and the counter-ion is part of the weighed article.

Molecular formula

A formula cannot be stated for a lot until the supplier declares the counter-ion, and no seller found does.

Average mass

159.212 Da for the cation C10H11N2+. 286.117 Da for the iodide C10H11IN2. The chloride C10H11ClN2 is 194.66 and the bromide C10H11BrN2 is 239.12. This spread is the whole problem with the article: iodide is 44.35% counter-ion by weight, so a lot weighed as the iodide but specified against the cation is 44% short of the stated substance, and the same lot specified against the chloride is 32% short. No single average mass belongs on a certificate until the salt form is declared.

Monoisotopic mass

159.0917 Da for the cation as an observed ion (atom-set monoisotopic 159.0922 less one electron mass, 0.00055 Da; the electron correction is below any tolerance stated in this catalog but is written out because a permanent cation is observed as [M]+ and not as [M+H]+). 285.9967 Da for the iodide C10H11IN2; 194.0611 for the chloride; 238.0106 for the bromide.

Salt / variant note

Confusables are cheap, aromatic and close in mass, which is the hazard with a 159 Da article. (1) the salt form against itself, and it is the largest error available: cation 159.21, chloride 194.66, bromide 239.12, iodide 286.12. Same number of molecules, up to 80% different in weight. No listing found states which is shipped. (2) 1-methylquinolinium with no amine, C10H10N+, 144.20 average / 144.0813 monoisotopic — the unaminated starting material, 15.02 Da lighter. (3) 5-aminoquinoline, C9H8N2, 144.18 average / 144.0688 monoisotopic — the un-methylated, uncharged precursor. Note (2) and (3) against each other: 144.20 against 144.18 average, 0.0126 Da apart monoisotopic, which is 87 ppm at m/z 144 and invisible to any unit-resolution instrument. A certificate reporting "MW 144" has identified neither. (4) 1-methylnicotinamide, C7H9N2O+, 137.16 / 137.0715, and nicotinamide, C6H6N2O, 122.13 / 122.0480 — both are pathway species, both are far cheaper, both are quaternary or pyridine solids that pass a bare RP-HPLC purity test. (5) Positional isomers: the amine can sit at ring positions 3, 4, 6, 7 or 8 and every one of them is exactly isobaric with the 5-amino article at any resolution. Only NMR or a co-eluting authentic standard separates them, and no reference standard for this compound is in commercial circulation.

2 Class & testing panel

Form

Single article

Testing panel

P6 — panel definition

3 Primary sources & evidence

The index reports the design and provenance of the literature, not a conclusion about effect.

In vitro (3T3-L1 adipocytes) plus mouse: Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Biochem Pharmacol 2018;147:141-152. PMID 29155147, DOI 10.1016/j.bcp.2017.11.007. In vitro (C2C12 myoblasts) plus mouse: Neelakantan H et al. Biochem Pharmacol 2019;163:481-492. PMID 30753815, DOI 10.1016/j.bcp.2019.02.008. Mouse: Dimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ. Sci Rep 2024;14:15554. DOI 10.1038/s41598-024-66034-9. Mouse: PMID 35013352. Analytical characterization of membrane permeability was by PAMPA and Caco-2 assay, reported within the 2018 paper. Human trial status: none identified. No registered trial of this compound or of the inhibitor class appears in ClinicalTrials.gov, and no human pharmacokinetic, dose-finding, safety or efficacy record was identified. No genotoxicity, carcinogenicity, reproductive or developmental toxicology has been published.

4 Storage & specification

Storage

Crystalline solid in an amber glass bottle with a desiccant sachet and a tamper-evident closure, headspace nitrogen-flushed. Labeled: store at -20 degrees C plus or minus 5 degrees C, protect from light, keep desiccated, close immediately after weighing. Quaternary ammonium salts take up water quickly in open air, so the desiccant and the close-immediately instruction are specifications rather than housekeeping. Reconstituted stock solutions are aliquoted single-use and held at -80 degrees C; no aqueous stock is refrozen. Ships ambient with a labeled cumulative excursion allowance of 120 hours at or below 30 degrees C recorded on the shipping record.

Shelf life

Shelf life is provisional at 24 months at -20 degrees C plus or minus 5 degrees C from the date of QA release. The interval is set on the company's own real-time and accelerated stability data, not on a supplier's certificate. Printed retest date on every unit, first-expiry-first-out enforced against that date.